3-(Trifluoromethyl)phenylboronic acid → HCID 59318023, compound

Participants

Reaction Steps

5′-(6-Methyl-3′-trifluoromethyl-biphenyl-3-ylcarbamoyl)-3,4,5,6-tetrahydro-2H-[1,2′]-bipyridinyl-4-carboxylic acid ethyl ester was prepared from 5′-(3-iodo-4-methyl-phenylcarbamoyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4 carboxylic acid ethyl ester and 3-trifluoromethylphenyl boronic acid following a method similar to the one described in the synthesis of 5′42-methyl-biphenyl-4-ylcarbamoyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-carboxylic acid ethyl ester above. The product was isolated after silica gel column purification with 20-40% EtOAc in hexanes gradient, HRMS m/z calcd for C28H28N3O3F3 [M+H]+: 512.2156. Found: 512.2155.

Provenance & Evidence