2,6-Dichloro-4-iodopyridine → 2,2',6,6'-Tetrachloro-4,4'-bipyridine

HRID 2190680Notes

Reaction equation

HRID 2190680 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](I)[CH:5]=[C:4]([Cl:9])[N:3]=1>[Cu]>[Cl:1][C:2]1[CH:7]=[C:6]([C:6]2[CH:5]=[C:4]([Cl:9])[N:3]=[C:2]([Cl:1])[CH:7]=2)[CH:5]=[C:4]([Cl:9])[N:3]=1

Participants

3

Reactant 1

HCID 117373932,6-Dichloro-4-iodopyridine

Product 1

HCID 142089092,2',6,6'-Tetrachloro-4,4'-bipyridine

Reagents, catalysts & solvents 1

HCID 23978CopperCatalyst2×

Procedure

a process of carrying out synthesis by stirring 2,6-dichloro-4-iodopyridine, listed as a starring material in Process (1-B), in the presence of a base by she catalysis of a copper catalyst such as copper powder with heating at 150° C. to 250° C. to yield 2,6,2′,6′-tetrachloro-[4,4′]bipyridyl, and treating this compound by the procedure of Process (B).

Workup

  1. customsynthesis
  2. temperaturewith heating at 150° C. to 250° C.

Sources & evidence

ORD record
ord-f118fd81b69a49bfa48e9b5c04cdd1f4
Source dataset
uspto-grants-2012_12
Patent number
US08324403B2

Reaction notes

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