HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 219072Generated: October 29, 2026
Sulfuric Acid → 4-((6-Phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline-7-carboxamide
https://huagongshe.com/reaction/219072
Participants
| Role | Name | HCID | Charge |
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| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 4-((6-Phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline-7-carbonitrile | HCID 25065132 | — |
| Product | 4-((6-Phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline-7-carboxamide | HCID 25065133 | — |
Reaction Steps
A mixture of 4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline-7-carbonitrile (0.300 g, 0.793 mmol) and SULFURIC ACID (3.00 ml, 56.3 mmol) was heated at 90° C. for 30 min. Quenched onto ice and sodium bicarbonate. Isolated solid by filtration and purified on RPHPLC. Fractions containing product were treated with 9% sodium carbonate. Removed volatiles. Product crashed out and was isolated by filtration. MS m/z=397.1 [M+1]+. Calc'd for C22H16N6O2: 396.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08198448B2 |
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| Source dataset | uspto-grants-2012_06 |
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| ORD ID | ord-284c93d92a2748f0be2d8f9aa87a99f1 |
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| Source note | uspto-grants-2012_06 |
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