HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Nitrite → (6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl-1H-[1,2,3]triazolo[4,5-c]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | N4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)pyridine-3,4-diamine | HCID 67503473 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | (6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl-1H-[1,2,3]triazolo[4,5-c]pyridine | HCID 57690935 | — |
Reaction Steps
To a solution of N4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)pyridine-3,4-diamine (0.0640 g, 0.202 mmol) in HOAc (5 mL) was added sodium nitrite (0.0153 g, 0.222 mmol) in water (2 mL). Stirred for 1 h. Concentrated. Took up in DMSO and purified on RPHPLC. Took fractions containing product and made basic with 9% sodium carbonate and removed volatiles in vacuo. Product crashed out and was isolated by filtration. MS m/z=329.2[M+1]+. Calc'd for C17H12N8: 328.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08198448B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-3aa28874a396461097832a46bd541fe8 |
| Source note | uspto-grants-2012_06 |