2-(3-Benzyloxypyridin-4-yl)-5-(trifluoromethyl)benzoxazole → 4-[5-(Trifluoromethyl)benzoxazole-2-yl]pyridin-3-ol

Participants

Reaction Steps

A mixture of 4.69 g of 2-(3-benzyloxypyridin-4-yl)-5-(trifluoromethyl)benzoxazole, 1.0 g of 5% palladium on carbon and 70 ml of acetic acid was stirred under about one atmosphere of hydrogen at room temperature for nine hours. The reaction mixture was filtered through Celite™. The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 3.44 g of 4-[5-(trifluoromethyl)benzoxazole-2-yl]pyridin-3-ol (hereinafter, referred to as “active compound 114”).

Provenance & Evidence