HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2190802Generated: October 30, 2026
Pyridine → N-(2-hydroxy-4-trifluoromethylphenyl)isonicotinamide
https://huagongshe.com/reaction/2190802
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Isonicotinic Acid | HCID 5922 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 2-Amino-5-(trifluoromethyl)phenol | HCID 15524277 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-(2-hydroxy-4-trifluoromethylphenyl)isonicotinamide | HCID 66881414 | 72.7% |
Reaction Steps
A mixture of 1.30 g of 2-amino-5-trifluoromethylphenol, 0.9 g of isonicotinic acid, 1.83 g of WSC and 15 ml of pyridine was stirred while heating at 80° C. for three hours. The mixture was cooled to room temperature, and then water was poured. Precipitated solid was filtered and washed with water, and then dried under reduced pressure to give 1.5 g of N-(2-hydroxy-4-trifluoromethylphenyl)isonicotinamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08324387B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-28b734ba553843cd9d4b67d4bc521ef5 |
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| Source note | uspto-grants-2012_12 |
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