Sodium Glycinate → HCID 54746544, compound

Participants

Reaction Steps

A mixture of 8-chloro-4-hydroxy-2-oxo-2H-chromene-3-carboxylic acid methyl ester (150 mg, 0.59 mmol) and glycine sodium salt (286 mg, 2.95 mmol) in 2-methoxyethanol (6 mL) was heated to reflux overnight. Reaction mixture was concentrated and dissolved in water (25 mL). The solution was acidified by 1 N aq HCl to pH=2-3 and extracted with EtOAc. Organic layer was washed with water, brine, dried over MgSO4, filtered and concentrated to give the title compound (135 mg). MS ESI(−) m/e: 296 (M−1).

Provenance & Evidence