2,3-Dimethylphenol → HCID 86649464, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,3-dimethyl-phenol (1.17 g, 9.57 mmol), 2-ethoxycarbonyl-malonic acid diethyl ester (4.1 mL, 19.1 mmol), and tin tetrachloride (23 μL, 0.19 mmol) was heated in a 200° C.-oil bath for 10 min; then cooled, the reaction mixture was directly purified on silica gel column chromatography (eluent: ethyl acetate in dichloromethane: 20% to 80%) to give the desired title product (18 mg). ESI (m/z): 263 (M+H)+.

Provenance & Evidence