Sodium Glycinate → HCID 54735959, compound

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Reaction Steps

A mixture of 7-bromo-4-hydroxy-2-oxo-2H-chromene-3-carboxylic acid methyl ester (example 11-b) (2.835 g, 9.47 mmol) and glycine sodium salt (13.8 g, 142.12 mmol) in 2-methoxyethanol (100 mL) was refluxed for 6 h; then cooled, solvent was evaporated, the residue was dissolved in water and acidified with 2 M HCl solution; the precipitates were collected via filtration, washed with water and air dried to give the desired title product (3.209 g). 1H NMR (200 MHz, DMSO-d6): δ (ppm)=18-12 (br, 2H), 9.79 (br, 1H), 7.85 (d, 1H, J=8.4 Hz), 7.7-7.5 (m, 2H), 4.05 (d, 2H, J=5.6 Hz).

Provenance & Evidence