Ethanol → HCID 86649468, compound

Participants

Reaction Steps

A mixture of [(7-bromo-4-hydroxy-2-oxo-2H-chromene-3-carbonyl)-amino]-acetic acid (3.209 g, 9.38 mmol) and thionyl chloride (2.05 mL, 28.1 mmol) in ethanol (75 mL) was refluxed for 2 h; then cooled, the precipitates were collected via filtration and washed with cold ethanol, air dried to give the desired product (3.153 g). 1H NMR (200 MHz, CDCl3): δ (ppm)=17.5 (s, 1H), 9.5 (br, 1H), 7.88 (dd, 1H, J=0.6 Hz, 8.4 Hz), 7.5-7.2 (m, 2H), 4.32-4.18 (m, 4H), 1.32 (t, 3H, J=7.0 Hz).

Provenance & Evidence