L-Alanine → HCID 54746589, compound

Participants

Reaction Steps

To a mixture of 5-(4-fluoro-benzyloxy)-4-hydroxy-2-oxo-2H-chromene-3-carboxylic acid methyl ester (86 mg, 0.25 mmol) and L-alanine (334 mg, 3.75 mmol) in 2-methoxyethanol was added sodium methoxide (176 mg, 3.25 mmol). Resulting mixture was refluxed overnight and concentrated. Residue was dissolved in water (100 mL) and acidified using 1 N HCl to pH=3-4. Precipitate was collected, rinsed with water and dried. Crude product was triturated with MeOH. Solid was collected and dried in vacuo to provide the title compound (61 mg). MS ESI(+) m/e: 402.13 (M+1).

Provenance & Evidence