L-Alanine → HCID 54746592, compound

Participants

Reaction Steps

A mixture of 5-(3-cyclopentyl-propoxy)-4-hydroxy-2-oxo-2H-chromene-3-carboxylic acid methyl ester (110 mg, 0.32 mmol) and L-alanine (424 mg, 4.76 mmol) in 2-methoxyethanol (9 mL) was added sodium methoxide (207 mg, 3.84 mmol). Resulting mixture was refluxed overnight and concentrated. Residue was dissolved in water (75 mL) and extracted with (1/1) EtOAc/hexanes which was discarded. The aqueous layer was acidified using 1 N HCl to pH=3-4 and extracted with EtOAc. Organic layer was washed with water, brine, dried over MgSO4, filtered and concentrated to provide the title compound (99.4 mg). MS ESI(−) m/e: 402.10 (M−1).

Provenance & Evidence