L-Alanine → HCID 54746594, compound

Participants

Reaction Steps

A mixture of 7-cyclohexyloxy-4-hydroxy-2-oxo-2H-chromene-3-carboxylic acid methyl ester (80 mg, 0.25 mmol), L-alanine (224 mg, 2.5 mmol) and sodium methoxide (108 mg, 2 mmol) in 2-methoxyethanol (3.5 mL) was microwaved at 150° C. for 2 h and then concentrated. Residue was dissolved in water (70 mL) and extracted with (1/1) EtOAc/hexanes which was discarded. The aqueous layer was acidified using 1 N HCl to pH=3-4 and extracted with EtOAc (2×). Combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated to provide the title compound (68 mg). MS ESI(−) m/e: 374.07 (M−1).

Provenance & Evidence