Hydrochloric Acid → HCID 66954873, compound

Participants

Reaction Steps

(5)-2-(tert-butoxycarbonylamino)-5-cyclopropyl-4,4-difluoropentanoic acid (75 g, 0.256 mol, 1 eq), prepared as in Example 10, was added to a 2 L round bottomed flask fitted with a mechanical stirrer, nitrogen inlet and thermometer. A mixture of hydrochloric acid (13.7 g, 0.375 mol, 1.5 eq) and acetonitrile (750 mL) and was added. White solids precipitated out during the reaction. After 2 hours the solids were filtered, washed with acetonitrile and dried in a vacuum oven at 30° C. for 24 hours to provide (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid hydrochloride (51 g, 87% yield). 1H NMR confirmed the desired structure.

Provenance & Evidence