HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (1,1'-Biphenyl)-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Reactant | 4'-[17beta-Hydroxy-17alpha-methyl-3-oxo-oestra-4,15-dien-11beta-yl][1,1'-biphenyl]-4-carbonitrile | HCID 67686215 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | (1,1'-Biphenyl)-4-carbonitrile | HCID 18021 | — |
Reaction Steps
260 mg of 4'-[3,3-[1,2-ethanediylbis(oxy)]-17β-methoxy-17α-methyloestra-5,15-dien-11β-yl][1,1'-biphenyl]-4-carbonitrile are reacted with 0.7 ml of 4 normal aqueous hydrochloric acid in 14 ml of acetone in the manner described in Example 1 r). Column chromatography on silica gel with a mixture of hexane/ethyl acetate yields 218 mg of 4'-17β-methoxy-17α-methyl-3-oxo-oestra-4,15-dien-11β-yl][1,1'-biphenyl]-4-carbonitrile in the form of a white foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05426102 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-2c9353d9d1a145118a5403d56857deda |
| Source note | uspto-grants-1995_06 |