HCID 72247288, compound → HCID 72247317, compound

HRID 2191007Notes

Reaction equation

[CH2:1]([O:3][P:4]([C:9]([F:39])=[CH:10][CH:11]1[CH:18]2[CH:14]([O:15]C(C)(C)[O:17]2)[CH:13]([N:21]2[CH:29]=[N:28][C:27]3[C:22]2=[N:23][CH:24]=[N:25][C:26]=3[NH:30][C:31](=[O:38])[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[O:12]1)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2].C(OP(C=CC1C(O)C(O)C(N2C3N=CN=C(NC(=O)C4C=CC=CC=4)C=3N=N2)O1)(=O)OCC)C>>[CH2:6]([O:5][P:4]([C:9]([F:39])=[CH:10][CH:11]1[CH:18]([OH:17])[CH:14]([OH:15])[CH:13]([N:21]2[CH:29]=[N:28][C:27]3[C:22]2=[N:23][CH:24]=[N:25][C:26]=3[NH:30][C:31](=[O:38])[C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[O:12]1)(=[O:8])[O:3][CH2:1][CH3:2])[CH3:7]

Participants

Reactant 2

HCID 72247288HCID 72247288, compound

HCID 74948506HCID 74948506, compound

Product 1

HCID 72247317HCID 72247317, compoundYield 76%

Procedure

Compound 7.4 (70 mg, 76% yield) was synthesized from compound 7.3 (100 mg) using the procedure described for the preparation for compound 6.5. 1HNMR (300 MHz, CD3CN) δ 1.21-1.38 (m, 6H), 4.06-4.24 (m, 4H), 4.47 (s, 1H), 4.92 (s, 1H), 5.00 (s, 1H), 6.08 (d, 1H, J=4.8), 6.31-6.47 (m, 1H), 7.57-8.06 (m, 5H), 8.31 (s, 1H), 8.72 (s, 1H).

Sources & evidence

ORD record: ord-529b9819b87241ddbaff2b34ac9d7e3f
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08324179B2

Reaction notes

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