HCID 59289236, compound → HCID 59289365, compound

HRID 2191030Notes

Reaction equation

HRID 2191030 reaction equation
[C:1]([O:9][C@H:10]1[C@@H:14]([O:15][CH3:16])[C@H:13]([N:17]2[CH:25]=[N:24][C:23]3[C:18]2=[N:19][CH:20]=[N:21][C:22]=3[NH:26][C:27](=[O:34])[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[O:12][C@@H:11]1/[CH:35]=[CH:36]/[P:37]([O:43]C(C)C)([O:39]C(C)C)=[O:38])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(NC1NC(=O)C2N=CN(C3OC(C=CP(O)(O)=O)C(OC(=O)C4C=CC=CC=4)C3OC)C=2N=1)(=O)C(C)C>>[C:27]([NH:26][C:22]1[N:21]=[CH:20][N:19]=[C:18]2[C:23]=1[N:24]=[CH:25][N:17]2[C@@H:13]1[O:12][C@H:11](/[CH:35]=[CH:36]/[P:37](=[O:38])([OH:39])[OH:43])[C@@H:10]([O:9][C:1](=[O:8])[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C@H:14]1[O:15][CH3:16])(=[O:34])[C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 59289236HCID 59289236, compoundHCID 136381450HCID 136381450, compound

Product 1

HCID 59289365HCID 59289365, compoundYield 47.5%

Procedure

Compound 21.3 (124 mg, 47.5% yield) was synthesized from compound 21.2 (300 mg, 0.462 mmol) using the procedure described for the synthesis of compound 16.8.

Sources & evidence

ORD record
ord-86ef5b1ad4c045cca521378c5ecc94e3
Source dataset
uspto-grants-2012_12
Patent number
US08324179B2

Reaction notes

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