HCID 86641123, compound → HCID 59289251, compound

HRID 2191041Notes

Reaction equation

HRID 2191041 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([O:11][C@@H:12]2[C@H:16]3[O:17]C(C)(C)[O:19][CH2:20][C@H:15]3[O:14][C@@H:13]2[O:23][CH3:24])(=[O:10])=[O:9])=[CH:4][CH:3]=1>C(O)(=O)C.O>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([O:11][C@@H:12]2[C@@H:16]([OH:17])[C@@H:15]([CH2:20][OH:19])[O:14][C@@H:13]2[O:23][CH3:24])(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 86641123HCID 86641123, compound

Product 1

HCID 59289251HCID 59289251, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

Compound 35.4 (32.18 g, 89.9 mmol) was dissolved in 400 mL of a 3:1 mixture of acetic acid and water. The mixture was heated to 50° C. for 2 h and the solvent was removed under reduced pressure. The residue was subjected to a column chromatography eluting with EtOAc to give compound 35.5.

Workup

  1. customthe solvent was removed under reduced pressure
  2. washeluting with EtOAc

Sources & evidence

ORD record
ord-c5fde4042bc2468d92e457bd8b6fdac7
Source dataset
uspto-grants-2012_12
Patent number
US08324179B2

Reaction notes

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