Benzyl Bromide → HCID 86641125, compound

Participants

Reaction Conditions

Reaction Steps

Compound 35.6 (20 g, 137 mmol) was dissolved in 15 mL dioxane, cooled to 0° C. and treated with 60% NaH (6.0 g, 151 mmol). The mixture was stirred at 0° C. for 30 min and then treated with BnBr (18 mL, 151 mmol). The mixture was warmed to r.t., stirred for 3 h, and then quenched with 50 mL MeOH. The mixture was stirred for another 30 min and the solvent was evaporated under reduced pressure. The residue was subjected to a silica gel column chromatography eluting with 10-50% EtOAc in Hexane to give compound 35.7 (26.55 g, 82% yield).

Provenance & Evidence