HCID 10915366, compound → HCID 15614363, compound

Participants

Reaction Steps

A solution of 10% formic acid in MeOH (50 mL) was degassed under vacuum for 5 min, and then 20 mL of this solution was added under argon to Pd/C (450 mg). To this suspension, compound 35.10 (450 mg, 1.25 mmol) dissolved in 25 mL of the same solution was added dropwise while stirring. The reaction was monitored by LC-MS. When completed, 50 mL of water was added to the mixture. The catalyst was filtered off and the solvent was removed under reduced pressure. The residue was subjected to a silica gel column chromatography eluting with 0-50% EtOAc in Hexane to give compound 35.11 (270 mg, 80% yield).

Provenance & Evidence