HCID 136173388, compound → HCID 136351473, compound

HRID 2191048Notes

Reaction equation

[C:1]([O:9][C@@H:10]1[C@H:14]([F:15])[C@@H:13]([CH2:16][CH:17]([P:25]([O:30]CC)([O:27]CC)=[O:26])[S:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[O:12][C@H:11]1[N:33]1[CH:41]=[N:40][C:39]2[C:38](=[O:42])[NH:37][C:36]([NH:43][C:44](=[O:46])[CH3:45])=[N:35][C:34]1=2)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(NC1NC(=O)C2N=CN(C3OC(C=CP(O)(O)=O)C(OC(=O)C4C=CC=CC=4)C3OC)C=2N=1)(=O)C(C)C>>[C:44]([NH:43][C:36]1[NH:37][C:38](=[O:42])[C:39]2[N:40]=[CH:41][N:33]([C@@H:11]3[O:12][C@H:13]([CH2:16][CH:17]([P:25](=[O:26])([OH:27])[OH:30])[S:18][C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=4)[C@@H:14]([F:15])[C@H:10]3[O:9][C:1](=[O:8])[C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[C:34]=2[N:35]=1)(=[O:46])[CH3:45]

Participants

Reactant 2

HCID 136173388HCID 136173388, compound

HCID 136381450HCID 136381450, compound

Product 1

HCID 136351473HCID 136351473, compoundYield 66.2%

Procedure

Compound 35.16 (45 mg, 66% yield) was synthesized from compound 35.15 (77 mg, 0.11 mmol) using the procedure described for the preparation of compound 16.8.

Sources & evidence

ORD record: ord-3169f78f878546c1a8c4a71f7281c9a6
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08324179B2

Reaction notes

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