HCID 72247359, compound → HCID 68593093, compound

HRID 2191063Notes

Reaction equation

HRID 2191063 reaction equation
[C:1]1([S:7]([CH:9]([P:44]([OH:47])([OH:46])=[O:45])[CH2:10][CH:11]2[O:15][CH:14]([N:16]3[CH:24]=[N:23][C:22]4[C:17]3=[N:18][CH:19]=[N:20][C:21]=4[NH:25]C(=O)C3C=CC=CC=3)[CH:13]([O:34]C(=O)C3C=CC=CC=3)[CH:12]2[F:43])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.NC1NC(=O)C2N=CN([C@@H]3O[C@H](CC(P(=O)(O)O)SC4C=CC=CC=4)[C@@H](F)[C@H]3O)C=2N=1>>[NH2:25][C:21]1[N:20]=[CH:19][N:18]=[C:17]2[C:22]=1[N:23]=[CH:24][N:16]2[CH:14]1[O:15][CH:11]([CH2:10][CH:9]([P:44](=[O:45])([OH:46])[OH:47])[S:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[O:8])[CH:12]([F:43])[CH:13]1[OH:34]

Participants

3

Reactant 2

HCID 72247359HCID 72247359, compoundHCID 136173376HCID 136173376, compound

Product 1

HCID 68593093HCID 68593093, compoundYield 112%

Procedure

Compound 49.4 (190 mg, 100% yield) was synthesized from compound 49.3 (247 mg, 0.36 mmol) using the same procedure described for the preparation of compound 35.17.

Sources & evidence

ORD record
ord-0509bc0d78ce4ef9ba5c04e66394cacb
Source dataset
uspto-grants-2012_12
Patent number
US08324179B2

Reaction notes

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