Tetrabutylammonium Fluoride → HCID 86641133, compound

Participants

Reaction Conditions

Reaction Steps

Compound 50.2 (0.713 g, 1.06 mmol) was dissolved in 10 ml anhydrous THF was cooled to 0° C. Tetrabutyl ammonium fluoride (1.11 ml, 1N in THF, 1.11 mmol) was added dropwise and the reaction mixture was allowed to rise to room temperature. The reaction was stirred for 4 hr at room temperature while monitoring by TLC. When the reaction was complete by TLC the, solvent was removed under vacuum. The residue was re-dissolved in ethyl acetate (4 ml) and purified by column chromatography. Yield 0.300 g, 65.0%. Anal. 1H-NMR (CD3CN): δ 2.2 m 1H; 2.45 m 1H; 3.37 t 1H; 3.7 dd 1H; 3.97 dd 1H; 4.53 m 1H; 5.62 m 1H; 5.87 d 1H; 6.06 s 1H; 7.49-7.70 m 5H; 7.79 t 1H; 8.05 t 4H; 8.19 d 1H.

Provenance & Evidence