HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2191068Generated: November 1, 2026
Benzoic acid 5-(6-benzoylamino-purin-9-yl)-4-fluoro-2-trityloxymethyl-tetrahydro-furan-3-yl ester → Benzoic acid 5-(6-benzoylamino-purin-9-yl)-4-fluoro-2-hydroxymethyl-tetrahydro-furan-3-yl ester
https://huagongshe.com/reaction/2191068
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzoic acid 5-(6-benzoylamino-purin-9-yl)-4-fluoro-2-trityloxymethyl-tetrahydro-furan-3-yl ester | HCID 86641135 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Benzoic acid 5-(6-benzoylamino-purin-9-yl)-4-fluoro-2-hydroxymethyl-tetrahydro-furan-3-yl ester | HCID 72247312 | 56.8% |
Reaction Steps
Compound 55.3 (13.0 g, 17.4 mmol) was treated with 80% AcOH (100 mL) and stirred at 40° C. for 5 h. The solvent was removed in vacuo and the mixture was subjected to Combiflash purification (SiO2, 330 g, 0-100% EtOAc-hexanes gradient) which afforded 55.4 as a white solid (4.72 g, 45%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08324179B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-c1638f80f4c64d86a1412653eda7d954 |
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| Source note | uspto-grants-2012_12 |
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