1,2-Dichloroethane → 1-(1-Methyl-cyclopropanecarbonyl)-piperidine-4-carboxylic acid ethyl ester

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Reaction Steps

To a stirred solution of 14.4 g (0.144 mol) 1-methyl-cyclopropanecarboxylic acid in 200 mL DCM was added 27.1 g (0.141 mol) EDC, 19.10 g (0.141 g) HOBt and 35.93 mL (0.259 mol) Et3N. After 1 h at room temperature 18.9 g (0.12 mol) piperidine-4-carboxylic acid ethyl ester was added and the mixture was stirred at room temperature over night. The mixture was poured onto water and extracted with DCM. The combined organic phases were dried over Na2SO4 and concentrated under vacuum. Column chromatography (SiO2, EtOAc/H, 1:1) yielded 26.1 g (92%) of the title compound as a light yellow oil.

Provenance & Evidence