HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → (R)-1-[(3R,4R)-1-Benzyl-3-(4-chloro-phenyl)-piperidin-4-yl]-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 1-[(3R,4R)-1-Benzyl-3-(4-chloro-phenyl)-piperidin-4-yl]-ethanone | HCID 59438172 | — |
| Reactant | (RS)-1-[(3SR,4SR)-1-Benzyl-3-(4-chloro-phenyl)-piperidin-4-yl]-ethanol | HCID 68475389 | — |
| Product | (R)-1-[(3R,4R)-1-Benzyl-3-(4-chloro-phenyl)-piperidin-4-yl]-ethanol | HCID 59438134 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of (RS)-1-[(3SR,4SR)-1-Benzyl-3-(4-chloro-phenyl)-piperidin-4-yl]-ethanol (example 5 (d)) the title compounds were synthesized from 1-[(3R,4R)-1-Benzyl-3-(4-chloro-phenyl)-piperidin-4-yl]-ethanone through reduction with LiAlH4. (R)-1-[(3R,4R)-1-Benzyl-3-(4-chloro-phenyl)-piperidin-4-yl]-ethanol was obtained as off-white solid. MS (m/e): 330.1 [(M+H)+] and (S)-1-[(3R,4R)-1-Benzyl-3-(4-chloro-phenyl)-piperidin-4-yl]-ethanol was obtained as colorless viscous oil. MS (m/e): 330.1 [(M+H)+]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324248B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-45607ef9f8e34ad49f2ae0f7e5efee54 |
| Source note | uspto-grants-2012_12 |