HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-{(S)-1-[(3S,4S)-3-(4-Chloro-phenyl)-piperidin-4-yl]-ethoxy}-nicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-{(S)-1-[(3S,4S)-1-Benzyl-3-(4-chloro-phenyl)-piperidin-4-yl]-ethoxy}-5-trifluoromethyl-pyridine | HCID 59438175 | — |
| Reactant | 5-chloro-2-[(3RS, 4RS)-3-(4-chloro-phenyl)-piperidin-4-ylmethoxy]-pyridine | HCID 71205557 | — |
| Product | 6-{(S)-1-[(3S,4S)-3-(4-Chloro-phenyl)-piperidin-4-yl]-ethoxy}-nicotinonitrile | HCID 59438147 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of 5-chloro-2-[(3RS, 4RS)-3-(4-chloro-phenyl)-piperidin-4-ylmethoxy]-pyridine; hydrochloride (example 1, step h) the title compound was prepared from 2-{(S)-1-[(3S,4S)-1-Benzyl-3-(4-chloro-phenyl)-piperidin-4-yl]-ethoxy}-5-trifluoromethyl-pyridine as white foam as the respective HCl salt. MS (m/e): 342.1 [(M+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324248B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-c2d6afed470545a5b6c27ed376d8046e |
| Source note | uspto-grants-2012_12 |