HCID 59438150, compound → HCID 68479370, compound

HRID 2191120Notes

Reaction equation

HRID 2191120 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH2:7][CH2:8][N:9](CC2C=CC=CC=2)[CH2:10][C:11]=1[C:12]1[CH:17]=[CH:16][C:15]([F:18])=[C:14]([F:19])[CH:13]=1)=[O:5])[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][C:4]([CH:6]1[CH2:7][CH2:8][NH:9][CH2:10][CH:11]1[C:12]1[CH:17]=[CH:16][C:15]([F:18])=[C:14]([F:19])[CH:13]=1)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 59438150HCID 59438150, compound

Product 1

HCID 68479370HCID 68479370, compoundYield 97.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 2.73 g (7.6 mmol) 1-benzyl-5-(3,4-difluoro-phenyl)-1,2,3,6-tetrahydro-pyridine-4-carboxylic acid ethyl ester in 150 mL ethanol was hydrogenated over 600 mg Pd/C (10%). The catalyst was filtered off and the filtrate was evaporated to dryness to yield 2 g (87%) of the title compound which was used without further purification in the subsequent step. MS (m/e): 270.3 [(M+H)+].

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-ef4e4fd2ec304278a80a022e235d583f
Source dataset
uspto-grants-2012_12
Patent number
US08324248B2

Reaction notes

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