Sodium Hydroxide → HCID 68473945, compound

Participants

Reaction Steps

A mixture of 1.5 g (4.2 mmol) (3SR,4SR)-3-(3,4-Difluoro-phenyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester and 0.16 g (4.2 mmol) LiAlH4 in 50 mL THF was stirred at room temperature for 1 h. Ethyl acetate, THF, water and NaOH aq. was added. Na2SO4 was added, the mixture was filtered off and evaporated to dryness. The residue was subjected to column chromatography on silica eluting with a gradient formed from ethyl acetate and heptane to afford after evaporation of the product containing fractions 1.06 g (77%) of the title compound as viscous colorless oil. MS (m/e): 228.1 [(M+H-Boc)+].

Provenance & Evidence