反应详情

A solution of 1.6 g (4.7 mmol) 1-[(3S,4S)-1-Benzyl-3-(4-chloro-phenyl)-piperidin-4-yl]-ethanone oxime in 300 mL methanol was hydrogenated over Raney Nickel (3.5 bar, 30° C., 23 h). The mixture was filtered and evaporated to dryness. The residue was purified by column chromatography over silica eluting with a gradient formed from DCM, methanol and NH3aq. to yield after evaporation of the product containing fractions 0.7 g (45%) of the title compound as colorless viscous oil. MS (m/e): 329.4 [(M+H)+].

1. filtrationThe mixture was filtered
2. customevaporated to dryness
3. customThe residue was purified by column chromatography over silica eluting with a gradient
4. customformed from DCM, methanol and NH3aq
5. customto yield
6. customafter evaporation of the product
7. additioncontaining fractions 0.7 g (45%) of the title compound as colorless viscous oil