HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxypyridine → 2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxypyridine | HCID 7971 | — |
| Reactant | (S)-tert-Butyl 2-(phenoxymethyl)pyrrolidine-1-carboxylate | HCID 10636271 | — |
| Product | 2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 21851782 | 61% |
Reaction Steps
2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (19) was prepared according to the same procedure for compound 9, except using 3-hydroxypyridine. The crude product was purified with ether to afford 1.70 g (61%) of 19 as a colorless oil. 1H NMR (300 MHz, CDCl3) δ 8.32 (s, 1H), 8.21 (s, 1H), 7.21 (m, 2H), 4.16 (m, 2H), 3.99-3.86 (m, 1H), 3.38 (m, 2H), 2.05-1.84 (m, 4H), 1.47 (s, 9H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329686B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-0a8616bc41e044808ac594c86f1f04c2 |
| Source note | uspto-grants-2012_12 |