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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2191247Generated: November 2, 2026

HCID 68932330, compound → HCID 73320859, compound

https://huagongshe.com/reaction/2191247

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 68932330HCID 68932330—
ReactantHCID 73320783HCID 73320783—
ProductHCID 73320859HCID 7332085945%

Reaction Steps

2-{1-(4-Bromo-benzyl)-2-oxo-5-[2-(pyndine-3-yloxymethyl)-pyrrolidine-1-sulfonyl]-1,2-dihydro-indol-3-yl-idene}-malononitrile (30c) was prepared according to the same procedure for compound 26 except using 28c, to afford 16 mg (45%) of 30c as a purple solid, mp 232.3° C. (decomp). 1H NMR (300 MHz, CDCl3) δ 8.50 (s, 1H), 8.21 (m, 1H), 8.16 (s, 1H), 7.96 (d, J=8.4 Hz, 1H), 7.51 (d, J=8.1 Hz, 2H), 7.20 (m, 4H), 6.84 (d, J=8.7 Hz, 1H), 4.89 (m, 2H), 4.20 (m, 1H), 4.02 (m, 2H), 2.05-1.78 (m, 4H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08329686B2
Source datasetuspto-grants-2012_12
ORD IDord-331b8d93b40b4b47b808b89e0e8fc28f
Source noteuspto-grants-2012_12