Sodium Hydroxide → HCID 68429508, compound

Participants

Reaction Steps

To a mixture of lithium aluminum hydride (0.066 g) and THF-diethyl ether (2 mL-10 mL) was added the compound obtained in step 2 (0.40 g), and the resulting mixture was stirred at room temperature for 3 hr under a nitrogen atmosphere. Lithium aluminum hydride (0.066 g) was added again, and the resulting mixture was stirred at room temperature for 2 hr under a nitrogen atmosphere. 1N Aqueous sodium hydroxide solution (0.13 mL), saturated aqueous ammonium chloride (0.13 mL) and water (0.13 mL) were added, and the resulting mixture was stirred at room temperature for 4 hr. The precipitate was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (solvent gradient; 0→40% ethyl acetate/hexane) to give 4-benzyl-8-phenoxy-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine (0.19 g, 50%) as a white powder.

Provenance & Evidence