Dimethylformamide → HCID 68428691, compound

Participants

Reaction Steps

A mixture of the compound obtained in Example 28, step 1 (0.50 g), isopropylthiol (0.20 potassium carbonate (0.51 g) and DMF (10 mL) was stirred at room temperature for 15 hr. The reaction solution was poured into water, and the resulting product was extracted with ethyl acetate. The organic layer was washed twice with water and saturated brine and dried, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (solvent gradient; 0→40% ethyl acetate/hexane) to give 4-benzyl-8-(isopropylthio)-3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one (0.38 g, 63%) as a white powder.

Provenance & Evidence