HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 71724478, compound → Sitagliptin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 71724478 | HCID 71724478 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Sitagliptin | HCID 4369359 | — |
Reaction Steps
Sitagliptin sulfate crystalline Form S3 can be prepared by a process comprising forming a solution of Sitagliptin base in ethyl acetate; combining the solution with sulfuric acid to form a precipitate; and isolating the obtained precipitate. Preferably, the sulfuric acid is used at a mol ratio of about 1:0.5 of Sitagliptin base to sulfuric acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329696B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-407642e9f50e4de0b12343d36299a07d |
| Source note | uspto-grants-2012_12 |