HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 131730100, compound → Sitagliptin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 131730100 | HCID 131730100 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Sitagliptin | HCID 4369359 | — |
Reaction Steps
Sitagliptin (S)-mandelate crystalline Form N4 can be prepared by a process comprising forming a solution of Sitagliptin base in acetone; combining the solution with mandelic acid to form a precipitate; and isolating the obtained precipitate. Preferably, the mandelic acid is used at a mol ratio of about 1:1 of Sitagliptin base to mandelic acid. Preferably, the acid is (S)-(+)-mandelic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329696B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-2dfac87439054cd4a368eff6c3ba2f25 |
| Source note | uspto-grants-2012_12 |