HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 131730059, compound → Sitagliptin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 131730059 | HCID 131730059 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | Sitagliptin | HCID 4369359 | — |
Reaction Steps
The amorphous Sitagliptin mandelate can be prepared by a process comprising forming a slurry of Sitagliptin base in methyl tert-butyl ether; combining the slurry with mandelic acid; and isolating the obtained precipitate. Preferably, the mandelic acid is used at a mol ratio of about 1:1 of Sitagliptin base to mandelic acid. Preferably, the acid is (S)-(+)-mandelic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329696B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-4b698be63a5146259c5de9f41bdc6dd3 |
| Source note | uspto-grants-2012_12 |