HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 86645865, compound → Sitagliptin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 86645865 | HCID 86645865 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | Sitagliptin | HCID 4369359 | — |
Reaction Steps
Sitagliptin lactate crystalline Form L3 can be prepared by a process comprising forming a slurry of Sitagliptin base in methyl tert-butyl ether; combining the slurry with lactic acid to form a precipitate; and isolating the obtained precipitate. Preferably, the lactic acid is used at a mol ratio of about 1:1 of Sitagliptin base to lactic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329696B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-84e0b1071f6343c79e9e06ca093f20f6 |
| Source note | uspto-grants-2012_12 |