Ammonia → 1-Amino-3-(morpholin-4-yl)propan-2-ol

4-Oxiranylmethyl-morpholine 53b (6.3 g, 44 mmol) was added slowly with ammonia (450 ml, 25%, 6.6 mol) while maintaining the temperature below 0° C. in an ice-water bath. Upon completion of the addition, the reaction mixture was allowed to warm up to room temperature and stirred for 18 hours. After thin lay chromatography showed the disappearance of starting materials, the reaction mixture was concentrated under reduced pressure to obtain the title compound 1-amino-3-morpholin-4-yl-propan-2-ol 53c (7 g, yield 99%) as a white solid.

1. temperaturewhile maintaining the temperature below 0° C. in an ice-water bath
2. additionUpon completion of the addition
3. concentrationthe reaction mixture was concentrated under reduced pressure

ORD record

ord-e61c3146ffb14503a41814c2e401bee0

Source dataset

uspto-grants-2012_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08329682B2