反应详情

温度

135 °C

3-Bromo-5-methoxypyridine (15 g) was added to a pressure vessel, and CUSO4 (3.9 g) and 25% aq. ammonia (150 mL) were added. The reaction mixture was stirred for 4 h at 135° C., then cooled to RT, basified with aqueous NaOH solution, and extracted with CH2Cl2. After evaporation of volatiles, 3-amino-5-methoxypyridine was obtained as yellow solid.

1. temperaturecooled to RT
2. extractionextracted with CH2Cl2
3. customAfter evaporation of volatiles