Acetyl chloride → HCID 67002083, compound

Participants

Reaction Conditions

Reaction Steps

In a 25 mL round-bottomed flask, 3-{[2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester (0.435 g, 0.84 mmol) was dissolved in MeOH (7 mL). The solution was cooled to 0° C. and acetyl chloride (1.2 mL, 16.8 mmol) was added dropwise over 10 min. The ice bath was removed and the reaction mixture was stirred at room temperature for 1.5 h. The solvent was evaporated at room temperature and the residue was dried under high vacuum to afford 402 mg of 2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid piperidin-3-ylamide hydrochloride as a light yellow foam which was used without further purification.

Provenance & Evidence