Lithium hydroxide, monohydrate → HCID 67001993, compound

Participants

Reaction Steps

To a solution of 1-cyclopropanecarbonyl-cyclopentane carboxylic acid methyl ester (0.62 g, 3.1 mmol) in EtOH (10 mL) were added LiOH.H2O (0.53 g, 12.6 mmol) and water (3 mL). The reaction mixture was stirred at room temperature overnight then diluted with water and washed with Et2O. The aqueous layer was acidified with conc. HCl to pH=2 then extracted with Et2O (2×). The combined second organic extracts were dried over Na2SO4 and concentrated to afford 0.36 g (64%) of 1-cyclopropanecarbonyl-cyclopentane carboxylic acid as a pale yellow oil.

Provenance & Evidence