Sodium Methoxide → 2,4-Dimethoxypyridine-3-carbaldehyde

HRID 2191600Notes

Reaction equation

HRID 2191600 reaction equation
[CH3:1][O:2][C:3]1C=C[C:6]2[C:7](C)=[N:8][O:9][C:5]=2[C:4]=1[CH:13]=[O:14].[CH3:15][O-].[Na+]>CO>[CH3:1][O:2][C:3]1[C:4]([CH:13]=[O:14])=[C:5]([O:9][CH3:15])[CH:6]=[CH:7][N:8]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 824037016-Methoxy-3-methylbenzo[d]isoxazole-7-carbaldehyde

Product 1

HCID 190732642,4-Dimethoxypyridine-3-carbaldehyde

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Reaction of the commercially available 2-chloro-4-methoxy-pyridine-3-carbaldehyde (23) with NaOMe in MeOH affords 2,4-dimethoxy-pyridine-3-carbaldehyde (24).

Sources & evidence

ORD record
ord-aa2cf0e5ef0f448da039903fb6a7de20
Source dataset
uspto-grants-2012_12
Patent number
US08329706B2

Reaction notes

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