Sulfuric Acid → HCID 66789630, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of acetone cyanhydrin (851 mg), 2,6-dimethoxybenzaldehyde (1.58 g) in AcOH (10 mL) is added at 10° C. dropwise H2SO4 (1 mL) and Ac2O (0.5 mL). The reaction mixture is stirred at 10° C. for 40 min and then 10 min at RT. The reaction mixture is poured into cracked ice and extracted three times with ether. The combined organic extracts are washed with 10% aq. NaHCO3, dried (Na2SO4), filtered and concentrated to yield a crude oil. FC (EtOAc) gives the title compound as a brown oil (1.3 g, 52%). LC-MS: tR=0.47 min; [M+H]+=252.25.

Provenance & Evidence