反应详情

温度

240 °C

A mixture of commercially available 2-hydroxyisobutyramide (638.5 mg, 3 eq), 2-benzyloxy-6-methoxy-benzaldehyde (500 mg) (Katritzky A. R. et al ARKIVOC 2001, 2, 3, 3-12) is heated at 240° C. for 5 min using microwave irradiation (Lecolier S. et al Chimica Therapeutica 1969, 4,6, 437-445). The crude oil is poured into water and extracted with DCM. The combined organic extracts are dried (MgSO4), filtered and concentrated to yield a crude oil. FC (EN n-heptane: 1/1 to 1/0) gives the title compound as a yellow solid (0.41 g, 61%); LC-MS: tR=0.65 min; [M+H]+=328.22.

1. custommicrowave irradiation (Lecolier S. et al Chimica Therapeutica 1969, 4,6, 437-445)
2. extractionextracted with DCM
3. dry with materialThe combined organic extracts are dried (MgSO4)
4. filtrationfiltered
5. concentrationconcentrated
6. customto yield a crude oil