HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Tert-butyl 4-amino-2-(4-fluoroanilino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Tert-butyl 2-(4-fluoroanilino)-4-nitrobenzoate | HCID 68965268 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Tert-butyl 4-amino-2-(4-fluoroanilino)benzoate | HCID 68958505 | 98.9% |
Reaction Steps
To a mixed solution of methanol 5.0 mL and ethyl acetate 5.0 mL of tert-butyl 2-(4-fluoroanilino)-4-nitrobenzoate 1.0 g, was added 5% palladium-carbon 0.20 g, and it was stirred under hydrogen atmosphere at room temperature for 6 hours. Insoluble matter was filtrated, the solvent was removed under reduced pressure to give tert-butyl 4-amino-2-(4-fluoroanilino)benzoate 0.90 g of white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08327467B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-bae4fca4e37d473b9650afdd9580ad9d |
| Source note | uspto-grants-2012_12 |