Hydrochloric Acid → HCID 57667922, compound

Participants

Reaction Steps

To N,N-dimethylformamide 5.0 mL solution of phenol 0.18 g were added potassium carbonate 0.50 g and methyl 4-(bromomethyl)-2-nitrobenzoate 0.50 g at room temperature, and it was stirred at same temperature for 10 hours. Ethyl acetate and 1.0 mol/L hydrochloric acid were added to the reaction mixture. The organic layer was separated and collected,dried over anhydrous magnesium sulfate after washing with saturated sodium chloride aqueous solution, and the solvent was removed under reduced pressure. The obtained residue was refined by silica gel column chromatography [eluent; hexane:ethyl acetate=6:1] to give methyl 2-nitro-4-(phenoxymethyl)benzoate 0.53 g of colorless oil.

Provenance & Evidence