Dimethylformamide → HCID 57667896, compound

Participants

Reaction Steps

To N,N-dimethylformamide 10 mL solution of methyl 4-(bromomethyl)-2-nitrobenzoate 1.0 g, were added potassium carbonate 1.0 g and benzenethiol 0.39 mL at room temperature, and it was stirred at same temperature for 7 hours. Ethyl acetate was added to the reaction mixture, insoluble matter was filtrated, and water was added to it. The organic layer was separated and collected,dried over anhydrous magnesium sulfate after sequential washing with saturated sodium hydrogen carbonate aqueous solution and saturated sodium chloride aqueous solution, the solvent was removed under reduced pressure. The obtained residue was refined by silica gel column chromatography [eluent; hexane:ethyl acetate=4:1] to give methyl 2-nitro-4-((phenylthio)methyl)benzoate 0.70 g of pale yellow oil.

Provenance & Evidence