Dimethylformamide → HCID 57667990, compound

Participants

Reaction Steps

To N,N-dimethylformamide 5.0 mL solution of 2-amino-4-phenoxybenzoic acid 0.40 g were added potassium carbonate 0.29 g and dimethyl sulfate 0.20 mL, and it was stirred at room temperature for 2 hours. Ethyl acetate was added to the reaction mixture, it was dried over anhydrous magnesium sulfate after sequential washing with saturated sodium hydrogen carbonate aqueous solution and saturated sodium chloride aqueous solution, and the solvent was removed under reduced pressure. The obtained residue was refined by silica gel column chromatography [eluent; hexane:ethyl acetate=10:1] to give methyl 2-amino-4-phenoxybenzoate 0.33 g of colorless oil.

Provenance & Evidence