Methanol → HCID 67343009, compound

Participants

Reaction Steps

To a mixed solution of methanol 11 mL and ethyl acetate 11 mL of tert-butyl 4-(3-chlorophenyl)-2-nitrobenzoate 1.1 g was added 10% palladium-carbon 0.33 g, and it was stirred under hydrogen atmosphere at room temperature for 3 hours. The solvent was removed under reduced pressure after insoluble matter was filtrated. To the obtained residue, were added acetic acid 11 mL, methanol 11 mL and 10% palladium-carbon 0.33 g sequentially, and it was stirred under hydrogen atmosphere at room temperature for 2 hours. The solvent was removed under reduced pressure after insoluble matter was filtrated to give tert-butyl 2-amino-4-(3-chlorophenyl)benzoate 0.70 g of white solid.

Provenance & Evidence